Endocrine Abstracts

KML001 is an orally bioavailable and water soluble trivalent arsenic compound having anti-cancer activity via controlling the numerous signaling pathways including phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) signaling pathways. PI3K/Akt and ERK signaling pathways are overactivated in adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. In this study, we evaluated the effects of KML001 on cell viability, cell cycle, apoptosis,...

Hirsutism, excessive terminal hair growth in a male-like pattern as a marker of hyperandrogenism, affects 5–10% of reproductive-age women worldwide. The frequency of hirsutism seems to decrease in Asians and the lower cut-off modified hirsutism score is suggested. We performed the study to estimate the frequency, bio-metabolic characteristics, correlates and determinants of hirsutism in reproductive aged Korean women. A total of 2682 female volunteers of reproductive age ...

The measurement of androgens is critical for the diagnosis of polycystic ovary syndrome (PCOS) but it has been difficult based on poor specificity and sensitivity of assays in the female range. The direct total androgen activity can be measured with dihydrotestosterone equivalent concentration (DEQ) using chemically activated luciferase gene expression (CALUX) bioassays. The aim of the study is to determine whether DEQ levels can be the index for hyperandrogenemia to be requir...

Background: The risk of iodine-induced thyrotoxicosis is increased in patients with Graves’ disease and multi nodular goiter with thyroid autonomy. At same time, hypothyroidism can develop after iodine exposure in patients with Hashimoto’s thyroiditis. But, there are no studies about the influence of iodine containing contrast media on thyroid function in iodine excessive area. This study was done to evaluate the changes of thyroid function after coronary angiography...

Objective: The association between albuminuria and peripheral artery disease (PAD) could be confounded by renal function. Albuminuria reflects generalized disruption of endothelial cell function. This study was conducted to examine the association of PAD with low glomerular filtration rate (GFR) and albuminuria in diabetic patients.Methods: A total of 254 diabetic patients were included. We examined the age, sex, duration of diabetes, GFR, urinary albumi...

Obesity is one of the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity. Several indicators of abdominal obesity such as body mass index (BMI) and waist circumference (WC) are available. BMI and WC have limitations in stratifying cardio-metabolic risks. Another obesity measure, A Body Shape Index (ABSI), has been introduced but its applicability remains limited. To address this, the z-score of the log-transformed ABSI (LBSIZ) was recently develope...

The prevalence of polycystic ovary syndrome (PCOS) is generally estimated at 5–7% in women of reproductive age. But studies regarding the prevalence of PCOS have largely been confined to non-Asians. We aimed to estimate prevalence and phenotype of PCOS in Korean women. Cross sectional study was done between November 2008 and May 2009. A questionnaire based on menstrual history and clinical manifestations of hyperandrogenism was utilized to find out ‘probable cases&#1...

Somatostatin analogues (SSA) are widely used for the treatment of patients with acromegaly, and the responses are variable. We investigated the possible predictive factors of the response to SSA therapy in Korean acromegalic patients. Twenty-eight patients were retrospectively analysed, who were treated by surgery and adjunctively SSA. Somatostatin suppression tests (SST, hourly GH measurements for 3 h following 100 μg somatostatin injection) were done before SSAs were gi...

Introduction: The mortality rate from cardiovascular disease (CVD) among young adults has declined less than that in the older population, raising concerns about the increasing prevalence of obesity-related conditions including hypercholesterolemia in the younger population. We investigated the age-standardized mean levels of serum cholesterols and the prevalence, awareness, treatment and control rates of hyper-LDL-cholesterolemia based on age.Methods: N...

Introduction: Rutin (C27H30O16) is the major representative of the flavonol subclass of flavonoids. Rutin has wide variety of pharmacological activity, however there are not sufficient data in 3T3-L1 preadipocyte. In this study, we demonstrated that the effect of rutin on the proliferation of 3T3-L1 preadipocyte.Methods: The 3T3-L1 preadipocyte were treated with homocysteine (1 mM), rutin (30 μM) and rutin after homo...